Cortical Plasticity Induction by Pairing Subthalamic Nucleus Deep-Brain Stimulation and Primary Motor Cortical Transcranial Magnetic Stimulation in Parkinson's Disease.
Identifieur interne : 000040 ( France/Analysis ); précédent : 000039; suivant : 000041Cortical Plasticity Induction by Pairing Subthalamic Nucleus Deep-Brain Stimulation and Primary Motor Cortical Transcranial Magnetic Stimulation in Parkinson's Disease.
Auteurs : Kaviraja Udupa ; Nina Bahl ; Zhen Ni ; Carolyn Gunraj ; Filomena Mazzella ; Elena Moro [France] ; Mojgan Hodaie [Canada] ; Andres M. Lozano [Canada] ; Anthony E. Lang ; Robert Chen [Canada]Source :
- The Journal of neuroscience : the official journal of the Society for Neuroscience [ 1529-2401 ] ; 2016.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Deep Brain Stimulation (methods), Electromyography, Evoked Potentials, Motor (physiology), Female, Humans, Male, Middle Aged, Motor Cortex (physiology), Neuronal Plasticity (physiology), Parkinson Disease (therapy), Subthalamic Nucleus (physiology), Time Factors, Transcranial Magnetic Stimulation.
- MESH :
- methods : Deep Brain Stimulation.
- physiology : Evoked Potentials, Motor, Motor Cortex, Neuronal Plasticity, Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Aged, Analysis of Variance, Electromyography, Female, Humans, Male, Middle Aged, Time Factors, Transcranial Magnetic Stimulation.
Abstract
Noninvasive brain stimulation studies have shown abnormal motor cortical plasticity in Parkinson's disease (PD). These studies used peripheral nerve stimulation paired with transcranial magnetic stimulation (TMS) to primary motor cortex (M1) at specific intervals to induce plasticity. Induction of cortical plasticity through stimulation of the basal ganglia (BG)-M1 connections has not been studied. In the present study, we used a novel technique of plasticity induction by repeated pairing of deep-brain stimulation (DBS) of the BG with M1 stimulation using TMS. We hypothesize that repeated pairing of subthalamic nucleus (STN)-DBS and M1-TMS at specific time intervals will lead to plasticity in the M1. Ten PD human patients with STN-DBS were studied in the on-medication state with DBS set to 3 Hz. The interstimulus intervals (ISIs) between STN-DBS and TMS that produced cortical facilitation were determined individually for each patient. Three plasticity induction conditions with repeated pairings (180 times) at specific ISIs (∼ 3 and ∼ 23 ms) that produced cortical facilitation and a control ISI of 167 ms were tested in random order. Repeated pairing of STN-DBS and M1-TMS at short (∼ 3 ms) and medium (∼ 23 ms) latencies increased M1 excitability that lasted for at least 45 min, whereas the control condition (fixed ISI of 167 ms) had no effect. There were no specific changes in motor thresholds, intracortical circuits, or recruitment curves. Our results indicate that paired-associative cortical plasticity can be induced by repeated STN and M1 stimulation at specific intervals. These results show that STN-DBS can modulate cortical plasticity.
DOI: 10.1523/JNEUROSCI.2499-15.2016
PubMed: 26758832
Affiliations:
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Safra Program in Parkinson's Disease, Division of Neurology and Robert.Chen@uhn.ca.</nlm:affiliation><country wicri:rule="url">Canada</country><wicri:regionArea>Edmond J. 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Safra Program in Parkinson's Disease, Division of Neurology and.</nlm:affiliation><wicri:noCountry code="subField">Division of Neurology and</wicri:noCountry></affiliation></author><author><name sortKey="Bahl, Nina" sort="Bahl, Nina" uniqKey="Bahl N" first="Nina" last="Bahl">Nina Bahl</name><affiliation><nlm:affiliation>Edmond J. Safra Program in Parkinson's Disease, Division of Neurology and.</nlm:affiliation><wicri:noCountry code="subField">Division of Neurology and</wicri:noCountry></affiliation></author><author><name sortKey="Ni, Zhen" sort="Ni, Zhen" uniqKey="Ni Z" first="Zhen" last="Ni">Zhen Ni</name><affiliation><nlm:affiliation>Edmond J. Safra Program in Parkinson's Disease, Division of Neurology and.</nlm:affiliation><wicri:noCountry code="subField">Division of Neurology and</wicri:noCountry></affiliation></author><author><name sortKey="Gunraj, Carolyn" sort="Gunraj, Carolyn" uniqKey="Gunraj C" first="Carolyn" last="Gunraj">Carolyn Gunraj</name><affiliation><nlm:affiliation>Edmond J. Safra Program in Parkinson's Disease, Division of Neurology and.</nlm:affiliation><wicri:noCountry code="subField">Division of Neurology and</wicri:noCountry></affiliation></author><author><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name><affiliation><nlm:affiliation>Edmond J. Safra Program in Parkinson's Disease, Division of Neurology and Brain and Spinal Cord Rehabilitation Program, Toronto Rehabilitation, University Health Network, University of Toronto, Toronto, Ontario M4G 3V9, Canada, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation wicri:level="3"><nlm:affiliation>Edmond J. Safra Program in Parkinson's Disease, Division of Neurology and Service de Neurologie, CHU Grenoble, Joseph Fourier University, Grenoble 38041, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Edmond J. Safra Program in Parkinson's Disease, Division of Neurology and Service de Neurologie, CHU Grenoble, Joseph Fourier University, Grenoble 38041</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Hodaie, Mojgan" sort="Hodaie, Mojgan" uniqKey="Hodaie M" first="Mojgan" last="Hodaie">Mojgan Hodaie</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurosurgery, Krembil Neuroscience Centre, Toronto Western Research Institute, Toronto, Ontario M5T 2S8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Krembil Neuroscience Centre, Toronto Western Research Institute, Toronto, Ontario M5T 2S8</wicri:regionArea><wicri:noRegion>Ontario M5T 2S8</wicri:noRegion></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurosurgery, Krembil Neuroscience Centre, Toronto Western Research Institute, Toronto, Ontario M5T 2S8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Krembil Neuroscience Centre, Toronto Western Research Institute, Toronto, Ontario M5T 2S8</wicri:regionArea><wicri:noRegion>Ontario M5T 2S8</wicri:noRegion></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name><affiliation><nlm:affiliation>Edmond J. Safra Program in Parkinson's Disease, Division of Neurology and.</nlm:affiliation><wicri:noCountry code="subField">Division of Neurology and</wicri:noCountry></affiliation></author><author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name><affiliation wicri:level="1"><nlm:affiliation>Edmond J. Safra Program in Parkinson's Disease, Division of Neurology and Robert.Chen@uhn.ca.</nlm:affiliation><country wicri:rule="url">Canada</country><wicri:regionArea>Edmond J. Safra Program in Parkinson's Disease</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Journal of neuroscience : the official journal of the Society for Neuroscience</title><idno type="eISSN">1529-2401</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Deep Brain Stimulation (methods)</term><term>Electromyography</term><term>Evoked Potentials, Motor (physiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (physiology)</term><term>Neuronal Plasticity (physiology)</term><term>Parkinson Disease (therapy)</term><term>Subthalamic Nucleus (physiology)</term><term>Time Factors</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Motor</term><term>Motor Cortex</term><term>Neuronal Plasticity</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Time Factors</term><term>Transcranial Magnetic Stimulation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Noninvasive brain stimulation studies have shown abnormal motor cortical plasticity in Parkinson's disease (PD). These studies used peripheral nerve stimulation paired with transcranial magnetic stimulation (TMS) to primary motor cortex (M1) at specific intervals to induce plasticity. Induction of cortical plasticity through stimulation of the basal ganglia (BG)-M1 connections has not been studied. In the present study, we used a novel technique of plasticity induction by repeated pairing of deep-brain stimulation (DBS) of the BG with M1 stimulation using TMS. We hypothesize that repeated pairing of subthalamic nucleus (STN)-DBS and M1-TMS at specific time intervals will lead to plasticity in the M1. Ten PD human patients with STN-DBS were studied in the on-medication state with DBS set to 3 Hz. The interstimulus intervals (ISIs) between STN-DBS and TMS that produced cortical facilitation were determined individually for each patient. Three plasticity induction conditions with repeated pairings (180 times) at specific ISIs (∼ 3 and ∼ 23 ms) that produced cortical facilitation and a control ISI of 167 ms were tested in random order. Repeated pairing of STN-DBS and M1-TMS at short (∼ 3 ms) and medium (∼ 23 ms) latencies increased M1 excitability that lasted for at least 45 min, whereas the control condition (fixed ISI of 167 ms) had no effect. There were no specific changes in motor thresholds, intracortical circuits, or recruitment curves. Our results indicate that paired-associative cortical plasticity can be induced by repeated STN and M1 stimulation at specific intervals. These results show that STN-DBS can modulate cortical plasticity.</div></front></TEI><affiliations><list><country><li>Canada</li><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region></list><tree><noCountry><name sortKey="Bahl, Nina" sort="Bahl, Nina" uniqKey="Bahl N" first="Nina" last="Bahl">Nina Bahl</name><name sortKey="Gunraj, Carolyn" sort="Gunraj, Carolyn" uniqKey="Gunraj C" first="Carolyn" last="Gunraj">Carolyn Gunraj</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name><name sortKey="Ni, Zhen" sort="Ni, Zhen" uniqKey="Ni Z" first="Zhen" last="Ni">Zhen Ni</name><name sortKey="Udupa, Kaviraja" sort="Udupa, Kaviraja" uniqKey="Udupa K" first="Kaviraja" last="Udupa">Kaviraja Udupa</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></region></country><country name="Canada"><noRegion><name sortKey="Hodaie, Mojgan" sort="Hodaie, Mojgan" uniqKey="Hodaie M" first="Mojgan" last="Hodaie">Mojgan Hodaie</name></noRegion><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. 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